CHAIN Nested Case-Cohort / Multi-Omics
Integrated biological research investigating mechanisms associated with mortality among acutely ill children.
Why this research began
Children with similar clinical diagnoses can have very different outcomes. Multi-omics looks beneath the visible clinical picture.
What the study asks
Which interacting biological pathways distinguish deterioration from recovery and may become intervention targets?
How the research works
Integrated proteomics, metabolomics, lipidomics, microbiome assessment, pathogen detection and enteropathy biomarkers using systems biology, multivariable modelling and machine learning.
Who contributes
Nested case-cohort samples and data from the CHAIN platform.
Where it takes place
Multinational CHAIN collaboration.
Study objectives
Integrate molecular, microbial and metabolic measurements.
Identify pathways associated with mortality and recovery.
Prioritise biological targets for future intervention.
Principal and contributing research team
Status and study timeline
- 01Sample selection
- 02Multi-omics laboratory analysis
- 03Integrated modelling
- 04Mechanism and target identification
Participating and collaborating institutions
Publications and findings
task_altAnalyses connect bedside observations with underlying biological pathways and systems-level data.
Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population
Nyirenda, J.; Hardy, O.M.; Da Silva Filho, J.; Herder, V.; et al. — Nature Medicine 30: 3765–3777
Intestinal disturbances associated with mortality of children with complicated severe malnutrition
MNRG and collaborating investigators — Communications Medicine
Related news, documents and contact
Related updates
No related public updates have been published yet.
Study documents
Approved protocols, public summaries and shareable study materials are published through the research resources library.
Browse research resources arrow_forwardResearch contact
Contact MNRG for collaboration, study information or approved document requests.
Contact the research team arrow_forwardWhy it matters
The objective is not only prediction but identification of biological mechanisms that can guide future interventions.